Pathophysiology of COVID-19: known and unknown

The corona virus disease 2019 caused by severe acute respiratory syndrome corona virus-2 starts as a respiratory infection but can progress to multi-organ involvement with some very unique and unusual clinical presentations. This can appear at times puzzling and can account for significant morbidity and mortality. Understanding the pathophysiology of this disease can help reveal the various mechanisms of the progress of the disease and can explain the clinical symptoms and offer hope for prevention and treatment modalities.